Product & ReviewsAntibodies

5-Methylcytosine (5-mC) rabbit antibody (pAb), sample

Product Details

Cat. No.
61256
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Active Motif

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Description

5-Methylcytosine (5-Methylcytidine) is a modified base that is found in the DNA of plants and vertebrates. DNA methylation is an epigenetic event in which DNA methyltransferases (DNMTs) catalyze the reaction of a methyl group to the fifth carbon of cytosine in a CpG dinucleotide. This modification helps to control gene expression and is also involved in genomic imprinting, while aberrant DNA methylation is often associated with disease. The 5-methylcytosine antibody has been developed to discriminate between the modified base and its normal cytosine counterpart, allowing for gene promoter methylation analysis.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Not Species Specific
  • Isotype: IgG

Handling

  • Quantity: 10 ul
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Dot Blot (DB)
  • Methylated DNA Immunoprecipitation (MeDIP)
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