Product & ReviewsAntibodies
Abi-1 Antibody
Product Details
- Cat. No.
- 251822
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Abelson interactor 1 (Abi-1) negatively regulates cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Abi-1 plays a role in regulation of EGF-induced Erk pathway activation. Abi-1 is involved in cytoskeletal reorganization and EGFR signaling, and together with EPS8 participates in transduction of signals from Ras to Rac. A chromosomal aberration involving Abi-1 is a cause of acute leukemias.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Abi-1.
- Isotype: Rabbit Ig
- Gene: Q8IZP0
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Western Blotting (WB)