Product & ReviewsAntibodies
ABL1 (7B11) Antibody
Product Details
- Cat. No.
- 252799
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
c-ABL (Proto-oncogene c-Abl) is a protein kinase that regulates key processes linked to cell growth and survival. c-ABL regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. C-ABL localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. c-ABL regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. A chromosomal aberration involving c-ABL1 is a cause of chronic myeloid leukemia.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of ABL1(aa577-650) expressed in E. coli.
- Clone: 7B11D6
- Isotype: Mouse IgG1
- Gene: P00519
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)