Acetylcholinesterase (AChE, EC.3.1.1.7.) is an enzyme located in the postsynaptic membrane and in the muscle endplates, where it hydrolyses the neurotransmitter acetylcholin. AChE from brain is a tetramer (G4-AChE) with a molecular mass of 320 kDa, AChE from erythrocytes is a dimer (G2-AChE) with a molecular mass of 170 kDa. Detection of higher levels of AChE in amniotic fluid can indicate fetal malformations such as neural tube defects. This antibody is specific for brain AChE and does not recognize AChE from erythrocytes. The antibody can thus distinguish between mammalian brain AChE and erythrocyte AChE. There is a weak cross-reactivity with Torpedo marmorata AChE but none with AChE from electric eel or human BtChE.
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Bovine, Human, Mammalian
- Antigen: C-terminal 10 residues of brain acetylcholinesterase (human and bovine), absent from the erythrocyte enzyme.
- Clone: 4E11
- Isotype: Mouse IgG1/k
- Gene: P22303
- Quantity: 0.2 mg
- Storage: Store at 4°C. Product is guaranteed 6 months from the date of shipment.
- ELISA (ELISA)
- Western Blotting (WB)