Actin Monoclonal Antibody (ACTN05 (C4))

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins. For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Bovine, Chicken, Dog (Canine), Human, Mouse, Pig (Swine), Protozoa, Rabbit (Lapine), Rat
• Isotype: IgG1, kappa

• Quantity: 500 µL
• Storage: Store at 4°C
• Buffer: PBS, pH 7.4, with 0.2% BSA
• Specificity: 5

• Immunocytochemistry (ICC)
• Immunofluorescence (IF)
• Immunohistochemistry (IHC)
• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
• Immunoprecipitation (IP)
• Western Blotting (WB)