ACTR-IIB Antibody
Product Details
- Cat. No.
- 251300
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Activin receptor type-2B (ACTR-IIB), upon ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in ACTR-IIB are the cause of visceral heterotaxy autosomal type 4 (HTX4), a form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. HTX4 results in an abnormal arrangement of visceral organs and a wide variety of congenital defects.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Dog (Canine), Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ACTR-IIB.
- Isotype: Rabbit Ig
- Gene: Q13705
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)