ADAM 15 Antibody
Product Details
- Cat. No.
- 251996
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) is a metalloproteinase with gelatinolytic and collagenolytic activity. ADAM 15 plays a role in the wound healing process, mediating both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. ADAM 15 inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. ADAM 15 suppresses cell motility towards fibronectin by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. ADAM 15 cleaves E-cadherin in response to growth factor deprivation.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ADAM 15.
- Isotype: Rabbit Ig
- Gene: Q13444
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)