Product & ReviewsAntibodies
ADAM-TS7 Antibody
Product Details
- Cat. No.
- 250456
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS7) is a metalloprotease that degrades COMP. ADAM-TS7 is up-regulated in articular cartilage and synovium from arthritis patients. The spacer domain and the thrombospondin type-1 domain are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ADAM-TS7.
- Isotype: Rabbit Ig
- Gene: Q9UKP4
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)