Aggrecan Antibody
Product Details
- Cat. No.
- 251591
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
Aggrecan core protein (Cartilage-specific proteoglycan core protein) is a major component of extracellular matrix of cartilagenous tissues. The major function of aggrecan is to resist compression in cartilage. Aggrecan binds avidly to hyaluronic acid via an N-terminal globular region. Expression of aggrecan is restricited to cartilages in chondrocytes throughout the developing skeleton. Aggrecan contains mostly chondroitin sulfate and lesser keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. Defects in aggrecan are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) and spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN).
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Chicken, Human, Mouse, Pig (Swine), Rabbit (Lapine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human aggrecan.
- Isotype: Rabbit Ig
- Gene: P16112
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)