Agrin Antibody
Product Details
- Cat. No.
- 251545
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
Agrin is an essential extracellular matrix component that causes clustering of nicotinic acetylcholine receptors (nAChRs) and acetylcholine-esterase on the surface of muscle fibers of the neuromuscular junction. Agrin, MuSK and rapsyn are all essential components for AChR aggregation. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites increasing the predicted MW from 200 kDa to 600 kDa.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse agrin.
- Isotype: Rabbit Ig
- Gene: A2ASQ1
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)