AKR1C3 Antibody
Product Details
- Cat. No.
- 252019
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Aldo-keto reductase family 1 member C3 (AKR1C3) catalyzes the conversion of aldehydes and ketones to alcohols. AKR1C3 catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. AKR1C3 functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. AKR1C3 can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. AKR1C3 preferentially transforms androstenedione (4-dione) to testosterone. AKR1C3 is strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. AKR1C3 is also inhibited by the flavinoid rutin, and by selective serotonin inhibitors (SSRIs).
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human AKR1C3.
- Isotype: Rabbit Ig
- Gene: P42330
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blotting (WB)