Product & ReviewsAntibodies

anti-AAV VP1/VP2/VP3 mouse monoclonal, B1, lyophilized, purified

Product Details

Cat. No.
61058
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
PROGEN

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Description

B1 reacts with free VP1, VP2 and VP3 of adeno-associated virus (AAV) and at a very reduced degree with assembled capsids. VP1 and VP2 are highly enriched in the nucleus, while non-assembled VP3 is evenly distributed in the nucleus and the cytoplasm. Epitope mapping experiments (Wobus et al. 2000) identified aa726 to aa733 (C-terminus; common to all 3 VP proteins) as the specific binding region. The antibody is also useful for characterization of different stages of infection. Wobus, C. E. et al. Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection. J. Virol. 74, 9281–93 (2000).

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Adeno-Associated Virus
  • Antigen: AAV2 capsids
  • Clone: B1
  • Conjugate: unconjugated
  • Isotype: IgG1

Handling

  • Quantity: 50 µg
  • Storage: lyophilized antibody: 2-8°C; reconstituted antibody: short term at 2-8°C; for long term storage we recommend to add 0.5% BSA prior to storing in aliquots at -20°C; avoid freeze/thaw cycles

Applications

  • Affinity Chromatography (AC)
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • Western Blotting (WB)
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