anti-Cadherin 11 mouse monoclonal, 16A, supernatant
Product Details
- Cat. No.
- 18319
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
The cadherin gene family encodes calcium-dependent adhesion molecules that promote homophilic interactions among cells. All cadherins are single-pass transmembrane proteins with a variable number of extracellular domains (EC; 110 amino acids long). Classical cadherins consist of five EC domains and a conserved cytoplasmic domain and are divided in type I and type II subgroups. Type I comprises cadherin E, N, P, and R. Type II include cadherin-5, -6, -8, -11, and -12. Cadherin-11 (OB-cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of cadherin-11 has been found in brain, spinal cord, bone marrow and bone cells, and it is regulated in human endometrial glandular epithelial and stromal cells. Recently, cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested (but not in non-invasive cell lines), suggesting cadherin-11 as a potential marker for aggressive, invasive tumor subsets.Positive control: PC-3 cell line (human prostate cell line)
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: GST fusion protein of part of the extracellular domain of cadherin 1 (OB-Cadherin)
- Clone: 16A
- Conjugate: unconjugated
- Isotype: IgG1
Handling
- Quantity: 1 mL
- Storage: short term at 2-8°C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Applications
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)