Anti-CD4 monoclonal antibody, clone GK1.5 [R-PE]
Product Details
- Cat. No.
- CABT-45165RM
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
Rat Anti-Mouse CD4 monoclonal antibody for FC. Rat anti Mouse CD4 antibody, clone GK1.5 recognizes mouse CD4, a 55 kDa protein also known as Ly-4 and L3T4. CD4 is a single chain transmembraneous glycoprotein which belongs to the immunoglobulin superfamily, and is primarily expressed on peripheral blood monocytes and tissue macrophages. CD4 is also expressed on a subpopulation of regulatory T cells (CD4+ CD25+), which play a key role in the maintenance of self tolerance. Rat anti Mouse CD4 antibody, clone GK1.5 has been reported to block CD4+ T-cell activation. It blocks class II MHC antigen-specific binding, thereby inhibiting functions such as class II MHC antigen-specific proliferation and the release of lymphokines. It may also be used for in vivo and in vitro cell depletion of CD4+ T-cells. Flow Cytometry Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. Applications：FC
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Conjugate: R-PE
- Isotype: IgG2b
- Gene: 12504
Handling
- Quantity: 100 Tests
- Storage: Prior to reconstitution store at +4°C. Following reconstitution store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- Flow Cytometry (FC)