anti-CD54 (ICAM-1) mouse monoclonal,EBS-CD-031, purified
Product Details
- Cat. No.
- 691593
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
EBS-CD-031 was typed at the CD Workshop IV. Binding of EBS-CD-031 blocks cell adhesion through ICAM-1 as does ICAM-1 synthetic peptide JF9 (aa 367-394), suggesting the epitope of EBS-CD-031 lies between aa 367-394 (domain 1). ICAM-1 belongs to the immunoglobulin superfamily, C2 subset, is a transmembrane molecule of 90 kDa with 7 potential N-glycosylation sites. It is expressed on resting monocytes and endothelial cells and in response to inflammatory cytokines such as TNF-alpha, IL1 and IFN-gamma, can be highly upregulated on many other cells, e.g. on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes to integrin CD11a/CD18 (LFA 1) and to CD11b/CD18 (Mac 1). The interaction of CD54 with LFA 1 enhances antigen specific T-cell activation. CD54 also binds to CD43, fibrinogen, most human rhinoviruses and to Plasmodium falciparum infected erythrocytes. ICAM-1 may also be related to progression and metastasis of tumors.Positive control: Raji cells, MOLT 4 cells, Human tonsils, lymph node.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Raji Burkitt lymphoma cells
- Clone: EBS-CD-031
- Conjugate: unconjugated
- Isotype: IgG2b kappa
Handling
- Quantity: 1 mL (100 µg/ml)
- Storage: store at 2-8°C
Applications
- Flow Cytometry (FC)
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blotting (WB)