Anti-CD58 monoclonal antibody, clone MEM-63 [R-PE]
Product Details
- Cat. No.
- CABT-46495MH
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Mouse Anti-Human CD58 monoclonal antibody for FC. CD58, or LFA-3, is a membrane glycoprotein of 55-70kD. It occurs in two forms, one transmembrane with a cytoplasmic domain, the other form anchored in the membrane via a glycosylphosphatidylinositol tail. The complete amino acid sequence of both forms has been deduced from cDNA. It is heavily N-glycosylated. CD58 is a cell adhesion molecule which plays a critical role in facilitation of antigen specific recognition through interaction with CD2 on T lymphocytes. It is a member of the immunoglobulin superfamily of molecules. CD58 has a wide tissue distribution, being present on erythrocytes, platelets, monocytes, a subset of lymphocytes, bone marrow cells, epithelium and endothelial cells. There are approximately 5,000 CD58 molecules on each erythrocyte. There is reduced expression of CD58 on haemopoletic cells in individuals with paroxysmal nocturnal haemoglobinuria. Flow Cytometry Use 10ul of the suggested working dilution to label 106 cells in 100ul. Applications：FC
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Conjugate: R-PE
- Isotype: IgG1
- Gene: 965
Handling
- Quantity: 100 Tests
- Storage: Prior to reconstitution store at +4°C. Following reconstitution store at +4°C. This product should be stored undiluted. DO NOT FREEZE. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- Flow Cytometry (FC)