Anti-CSF3R monoclonal antibody, clone LMM775 [R-PE]

Mouse Anti-Human CSF3R monoclonal antibody for FC. Mouse anti Human CD114 antibody, clone LMM775recognises the human Granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114. CD114 is a 836 amino acid, single pass type I transmembrane glycoprotein, a crucial factor in the survival and maturation of cells in the neutrophilic lineage. CD114 contains a single Ig-like C2-type and five fibronectin type-III domains (UniProt: Q99062). Mouse anti Human CD114 antibody, clone LMM775 binds to an epitope located within the Ig-like domain but does not block binding of G-CSF to its receptor. Mouse anti Human CD114 antibody, clone LMM775 does not bind to a mutant G-CSF-R when the Ig-like domain has been substituted with the related gp130 Ig-like domain. G-CSF stimulates the production of neutrophils and accelerates their maturation in bone marrow. Expression of CD114 is down regulated on granulocytes but not monocytes following acute exposure to bacterial components including LPS with potential consequences for granulocyte function in the acute response to infection. The G-CSF-receptor on monocytes is functional, playing a role in the release of cytokines, either directly or indirectly following bacterial challange. The G-CSF receptor CD114 has also been implicated in the induction of β-1 integrin mediated adhesion and invasion of pancreatinc cancer cells. Flow Cytometry Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Applications：FC

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Conjugate: R-PE
• Isotype: IgG1
• Gene: 1441

• Quantity: 100 Tests
• Storage: Prior to reconstitution store at +4°C. Following reconstitution store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

• Flow Cytometry (FC)