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<p>The mouse monoclonal antibody localizes Dsc3 present in</p> <ul> <li>All living epidermal layers</li> <li>In glandular duct cells</li> <li>In basal matrix cells and outer root sheath of hair follicles</li> <li>Basal and suprabasal cell layers of stratified epithelia (e.g. vagina, tongue, esophagus), basal layer of bladder urothelium and complex epithelium of trachea</li> <li>Thymic reticulum cells</li> </ul> <p>All simple epithelia are negative. Intercalated disks of myocardium are<br> negative. Polypeptide reacting: 109 kDa and 100 kDa polypeptides (desmocollin 3 splice isoforms at pI 5.2) from human epidermal desmosomes.<br>Reactivity on cultured cell lines: most cultured cell lines derived from stratified squamous epithelia or squamous cell carcinomas are positive (e.g. A-431, HaCaT).</p>