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<p>DP1 + 2-2.15 shows distinct punctate membrane staining of different epithelia. Tumors specifically detected: primary and metastatic carcinoma and meningioma. Polypeptides reacting: Desmoplakin 1 and 2 (Mr 250,000 and 215,000).</p><p>The epitope recognized by clone DP1 + 2-2.15 is mapped to the N-terminus of the rod domain (Bornslaeger, E. A., 1996). Bornslaeger, E. A. Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. J. Cell Biol. 134, 985–1001 (1996).</p>