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Mouse anti-Human FLT1 monoclonal antibody for IHC-Fr; ELISA; IP. This product specifically recognises an epitope within amino acid residues 1-251 located in the extracellular domain of human VEGF (vascular endothelial growth factor) receptor 1 (VEGFR-1), otherwise known as Flt-1, a tyrosine-kinase receptor expressed by almost all vascular endothelial cells and by some peripheral blood monocytes. VEGFR-1 acts as a receptor for members of the VEGF protein family, playing a key role in vascular development and the regulation of vascular permeability. The signal transduction cascade resulting from VEGFR-1 binding appears to differ from that of VEGFR-2 (KDR), since the proliferation of cells lacking VEGFR-1 can be induced by VEGFR-2 binding, whilst the proliferation of cells lacking VEGFR-2, cannot be induced by VEGFR-1 binding alone. Applications：IHC-Fr; ELISA; IP