Product & ReviewsAntibodies

Anti-human Adiponectin

Product Details

Cat. No.
A369-100 µg
Clonality
Monoclonal
Host
Mouse
Leinco Technologies

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Description

Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It is induced during adipocyte differentiation, and its secretion is stimulated by insulin. It promotes adipocyte differentiation, fatty acid catabolism and insulin sensitivity. Adiponectin expression is negatively correlated with obesity, type 2 diabetes, and atherogenesis. Adiponectin is an anti-inflammatory agent, but it exerts pro-inflammatory effects in nonmetabolic disorders such as rheumatoid arthritis and inflammatory bowel disease. Adiponectin interacts with the receptors AdipoR1 and AdipoR2, calreticulin and Cadherin-13/T-Cadherin, as well as with several growth factors. Mature human Adiponectin shares 83% and 85% amino acid (aa) sequence identity with mouse and rat Adiponectin, respectively. The glycosylation of four hydroxylated lysine residues in the collagenous domain is required for the intracellular formation of HMW complexes. The various multimeric forms of Adiponectin exhibit distinct tissue specific and gender specific profiles and activities.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Clone: 166126
  • Conjugate: Purified No Carrier Protein
  • Isotype: IgG2b

Handling

  • Quantity: 100 µg
  • Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Applications

  • Immunohistochemistry (IHC)
  • In Situ Hybridization (ISH)
  • Neutralization (Neut)
  • Western Blotting (WB)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links