Anti-Human BA-R (CT)

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BA, BLyS, TALL-1, THANK, and zTNF4.1-4 BA/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.1,2 Two receptors, TACI and BCMA, for BA were originally identified. A third receptor was identified recently and designated BA-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BA and April, BA-R/BR3 is specific for BA and plays a predominant role in BA induced B cell development and survival. BA and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase.4

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human
• Conjugate: Purified No Carrier Protein

• Quantity: 0.1 mg
• Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

• Immunohistochemistry (IHC)
• In Situ Hybridization (ISH)
• Mass Cytometry (CyTOF)
• Neutralization (Neut)
• Western Blotting (WB)