Anti-Human Beta-Site APP Cleaving Enzyme 2 (NT) (BACE2)

Accumulation of the amyloid-β (αβ) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. αβ peptide is generated by proteolytic cleavage of the β-amyloid protein precursor (APP) at β- and γ-sites by proteases. The long-sought β-secretase was recently identified by several groups independently and designated β-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2).1-4 A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1.4-9 BACE2 also cleaves APP at β-site and at a different site within αβ.8 BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and αβ may also contribute to the pathogenesis of Down syndrome.6,7

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human
• Conjugate: Purified No Carrier Protein
• Gene: 25825

• Quantity: 0.1 mg
• Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

• Immunohistochemistry (IHC)
• Western Blotting (WB)