Product & ReviewsAntibodies
Anti-Human Caspase-3 Active Subunit (p17)
Product Details
- Cat. No.
- C1141-0.2 mg
- Clonality
- Monoclonal
- Host
- Mouse
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1,2 Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: C31.129
- Conjugate: Purified
- Isotype: IgG1
Handling
- Quantity: 0.2 mg
- Storage: This antibody does not contain preservatives and must be stored at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Applications
- Immunohistochemistry (IHC)
- Western Blotting (WB)