Product & ReviewsAntibodies
Anti-Human Caspase-3 - DyLight® 650
Product Details
- Cat. No.
- C1772- 50 µg
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1,2 Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: C31.129
- Conjugate: DyLight® 650
- Isotype: IgG1
- Gene: 836
Handling
- Quantity: 50 µg
- Storage: This DyLight® 650 conjugate is stable when stored at 2-8°C. Do not freeze.
Applications
- In Situ Hybridization (ISH)