Anti-Human CD137 (4-1BB)

4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response. When binding its ligand, CD137 provides costimulatory signals to both CD4 and CD8 T cells via the activation of NF-B, c-Jun and p38 downstream pathways. Crosslinking of CD137 boosts T cell proliferation, IL-2 secretion, survival and cytolytic activity. Furthermore, it can increase immune activity to eliminate tumors in mice. Agonistic anti-CD137 antibodies have been reported to stimulate a more intense immune system attack on cancers.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Antigen: 4-1BB is expressed on activated B cells and T cells, macrophages, and dendritic cells.
• Clone: 145501
• Conjugate: Purified No Carrier Protein
• Isotype: IgG2b
• Gene: 3604

• Quantity: 25 µg
• Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

• ELISA (ELISA)
• Neutralization (Neut)
• Western Blotting (WB)