Product & ReviewsAntibodies
Anti-Human CD16 - Purified
Product Details
- Cat. No.
- C465
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CD16 is expressed in two forms: CD16a and CD16b. CD16a (γRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (γRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (γRIII) and CD16 (γRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: CD16 is expressed on NK cells, activated monocytes, macrophages, neutrophils, and placental trophoblasts.
- Clone: GRM1
- Conjugate: Purified
- Isotype: IgG2a
- Gene: 2214
Handling
- Quantity: 0.1 mg
Applications
- Immunoprecipitation (IP)
- In Situ Hybridization (ISH)