Anti-Human CD20 - Purified <i>In vivo </i>PLATINUM™ Functional Grade

CD20 is a 33-37 kD transmembrane-spanning phosphoprotein that facilitates optimal B-cell immune response against T-independent antigens. It can exist in a complex with MHC class I, MHC class II, CD53, CD81, and CD82. However, CD20 can also form homo-oligomers. It has been suggested that homo-oligomerization of CD20 forms calcium ion channels in the plasma membrane of B cells. CD20 can be useful in diagnosing B-cell lymphomas and leukemias, and is the target of mAbs in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. Interestingly, studies show a link between the immune system's B cells and diabetes mellitus in which anti-CD20 antibodies rendered the T cell antibodies dysfunctional and, hence, unable to cause insulin desensitivity by a B cell antibody-modulated autoimmune response.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Antigen: CD20 is present on human pre B lymphocytes and on B lymphocytes, except on plasma cells, and is expressed in tandem with surface IgM. It is also expressed in some follicular dendritic cells and at low levels on a T cell subset.
• Clone: 2H7
• Conjugate: Low Endotoxin Functional Formulation, PLATINUM
• Isotype: IgG2b κ
• Gene: 931

• Quantity: 25 mg
• Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

• Fluorescent Assay (FA)
• Immunochromatography (IC)
• Immunofluorescence (IF)
• Immunomicroscopy (IM)
• Immunoprecipitation (IP)
• In Situ Hybridization (ISH)
• Western Blotting (WB)