Anti-Human CD64 (GR1) - FITC
Product Details
- Cat. No.
- C694
- Clonality
- Monoclonal
- Host
- Mouse
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Description
GR1 antibody, 10.1, recognizes high-affinity immunoglobulin gamma receptor I (GR1), also known as CD64. GR1 is a 72 kDa type I transmembrane glycoprotein expressed on monocytes, macrophages, and dendritic cells (DCs). GR1 can also be induced on neutrophils with IFNγ and G-CSF1. GR1 binds with high affinity to monomeric IgG1 and IgG3, and to a lesser extent, IgG42, resulting in phosphorylation of the intracellular GR1 ITAM motif and subsequent recruitment of Syk. GR1 contributes to inflammation via several mechanisms, including promoting antibody-dependent cell-mediated cytotoxicity (ADCC), clearance of immune complexes, cytokine production, and antigen presentation1,3. CD64-based targeted therapies eliminate M1 pro-inflammatory macrophages and show clinical potential for the treatment of macrophage-mediated chronic inflammatory diseases, such as chronic cutaneous inflammation and rheumatoid arthritis4. In addition, CD64 promotes antitumor responses and mediates cytotoxic killing of tumor cells by macrophages5.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: GR1 is expressed on monocytes, macrophages, dendritic cells (DCs), and activated granulocytes.
- Clone: 10.1
- Conjugate: Fluorescein (FITC)
- Isotype: IgG1 κ
Handling
- Quantity: 100 µg
- Storage: This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.
Applications
- In Situ Hybridization (ISH)