Product & ReviewsAntibodies

Anti-Human CD64 (GR1) - PE

Product Details

Cat. No.
C695
Clonality
Monoclonal
Host
Mouse
Leinco Technologies

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Description

GR1 antibody, 10.1, recognizes high-affinity immunoglobulin gamma receptor I (GR1), also known as CD64. GR1 is a 72 kDa type I transmembrane glycoprotein expressed on monocytes, macrophages, and dendritic cells (DCs). GR1 can also be induced on neutrophils with IFNγ and G-CSF1. GR1 binds with high affinity to monomeric IgG1 and IgG3, and to a lesser extent, IgG42, resulting in phosphorylation of the intracellular GR1 ITAM motif and subsequent recruitment of Syk. GR1 contributes to inflammation via several mechanisms, including promoting antibody-dependent cell-mediated cytotoxicity (ADCC), clearance of immune complexes, cytokine production, and antigen presentation1,3. CD64-based targeted therapies eliminate M1 pro-inflammatory macrophages and show clinical potential for the treatment of macrophage-mediated chronic inflammatory diseases, such as chronic cutaneous inflammation and rheumatoid arthritis4. In addition, CD64 promotes antitumor responses and mediates cytotoxic killing of tumor cells by macrophages5.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: GR1 is expressed on monocytes, macrophages, dendritic cells (DCs), and activated granulocytes.
  • Clone: 10.1
  • Conjugate: R-phycoerythrin (PE)
  • Isotype: IgG1 κ
  • Gene: 2209

Handling

  • Quantity: 100 µg
  • Storage: This R-phycoerythrin (R-PE) conjugate is stable when stored at 2-8°C. Do not freeze.

Applications

  • Immunoprecipitation (IP)
  • In Situ Hybridization (ISH)
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