Anti-Human CNTF (Clone 21809)
Product Details
- Cat. No.
- C1387
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Ciliary neurotrophic factor (CNTF) is a cytokine that supports survival and/or differentiation of a variety of neuronal cell types including sensory, sympathetic, and motoneurons.1,2 With these abilities, CNTF has implications for Parkinson's disease and cell-replacement therapies for other disorders.3 CNTF mimics the biological actions of leptin while overcoming "leptin resistance" and appears to reduce inflammatory signaling cascades associated with lipid accumulation in liver and skeletal muscle. The advantages and disadvantages of CNTF has shown promise as a therapeutic strategy to alleviate obesity-associated diseases.4
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: 21809
- Conjugate: Purified No Carrier Protein
- Isotype: IgG2a
Handling
- Quantity: 25 µg, 500 µg
- Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Applications
- ELISA (ELISA)
- In Situ Hybridization (ISH)
- Mass Cytometry (CyTOF)
- Neutralization (Neut)
- Western Blotting (WB)