Anti-Human FLASH (CT)
Product Details
- Cat. No.
- F138
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
A novel mammalian CED-4 homologous was recently identified and cloned in mouse1 and human2 and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8.1 There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.1,2 FLASH is widely expressed.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Conjugate: Purified No Carrier Protein
Handling
- Quantity: 0.1 mg
- Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Applications
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)