Anti-Human I-Kappa-B Kinase Gamma (NT) (IKKγ)

Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-κB activity. The IkB kinase (IKKα and IKKβ) phosphorylates IkB and mediates NF-κB activation. A novel molecule in the IKK complex was recently identified and termed IKKγ/NEMO/FIP3/IKKAP1.1-4 IKKg interacts with IKKβ and is required for the activation of IKK complex and NF-κB by LPS, PMA, TNF, and IL-1 stimulation.1-4 FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κB activation.3

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human
• Conjugate: Purified No Carrier Protein

• Quantity: 0.5 mg
• Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

• Immunohistochemistry (IHC)
• Western Blotting (WB)