Anti-Human ICAM-1 - Purified <i>In vivo </i>GOLD™ Functional Grade

ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Antigen: CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
• Clone: 15.2
• Conjugate: GOLD, Low Endotoxin Functional Formulation
• Isotype: IgG1
• Gene: 3383

• Quantity: 5.0 mg
• Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

• ELISA (ELISA)
• Immunohistochemistry (IHC)
• Western Blotting (WB)