Anti-Human IκB Kinase Alpha (CT-1) (IKKα)

Nuclear factor κ B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, and bacteria product LPS. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories.1-4 IKK is a serine protein kinase, and the IKK complex contains α and β subunits (IKKα and IKKβ). IKKa and IKKβ interact with each other and both are essential for the NF-κB activation. IKKα specifically phosphorylates IkB-α. IKKα is expressed in variety of human tissues.

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human
• Conjugate: Purified No Carrier Protein

• Quantity: 0.5 mg
• Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

• Immunohistochemistry (IHC)
• Western Blotting (WB)