Product & ReviewsAntibodies

Anti-Human IL-1 RII (Clone 34117)

Product Details

Cat. No.
I-641
Clonality
Monoclonal
Host
Mouse
Leinco Technologies

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Description

Interleukin 1 receptor type II (IL1R2), also known as CD121b (Cluster of Differentiation 121b), is a transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. It is a decoy receptor known for its ability to buffer IL-1 effects.1 IL-1RII is involved in the control of the proinflammatory state that takes place in the endometrium during the premenstrual and menstrual periods.2 IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis.3

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Clone: 34117
  • Conjugate: Purified No Carrier Protein
  • Isotype: IgG1

Handling

  • Quantity: 25 µg, 500 µg
  • Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Applications

  • Immunochromatography (IC)
  • Neutralization (Neut)
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