Anti-Human IL-12 (Clone 24910)
Product Details
- Cat. No.
- I-351-100 µg
- Clonality
- Monoclonal
- Host
- Mouse
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Description
IL-12 plays a role in resistance against pathogens via the differentiation of naive T cells into Th1 cells. It stimulates the growth and function of T cells, blocks formation of new blood vessels, and contributes to antimycobacterial immune response. In addition, it promotes the production of IFN-γ and TNF-α and reduces IL-4 mediated suppression of IFN-γ. Consequently, this enhances the immunostimulatory and immunomodulatory effects of IFN-γ. In addition, there appears to be a link between IL-2 and the signal transduction of IL-12 in NK cells, which enhances the functional response of IL-12 via IFN-γ production and killing of target cells. Furthermore, IL-12 is thought to be associated with autoimmunity. IL-12 was shown to worsen the condition when administered to people already suffering from autoimmune diseases. Comparatively, inhibition of IL-12 (either through IL-12 gene knock-out in mice or treatment of mice with IL-12 mAbs) improved the disease.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: 24910
- Conjugate: Purified No Carrier Protein
- Isotype: IgG1
Handling
- Quantity: 100 µg
- Storage: The lyophilized antibody should be stored desiccated at -20°C to -70°C. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Applications
- Neutralization (Neut)
- Western Blotting (WB)