Product & ReviewsAntibodies

Anti-Human IL-18 BPa

Product Details

Cat. No.
I-622-25 µg
Clonality
Monoclonal
Host
Mouse
Leinco Technologies

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Description

IL-18-binding protein (IL-18BP) is a secreted glycoprotein that functions as a natural anti-inflammatory and immunosuppressive molecule neutralizing the effects of high IL18 levels during inflammation.1 There are four variants of IL-18BP and IL18BPa is the predominant form showing the highest affinity towards IL18.1, 2 IL-18 BPa has the potential to amplify anti-inflammatory actions of immunosuppressive drugs, and thus may prove to be a valuable novel pharmacological component in the treatment of human autoimmune diseases.3

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Clone: 136033
  • Conjugate: Purified No Carrier Protein
  • Isotype: IgG1

Handling

  • Quantity: 25 µg
  • Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Applications

  • ELISA (ELISA)
  • Immunohistochemistry (IHC)
  • In Situ Hybridization (ISH)
  • Mass Cytometry (CyTOF)
  • Neutralization (Neut)
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