Anti-Human IL-23 (NT)

Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes.3,4 Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-γ, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human
• Conjugate: Purified No Carrier Protein
• Gene: 51561

• Quantity: 0.1 mg
• Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

• Immunohistochemistry (IHC)
• Western Blotting (WB)