Anti-Human IL-4 - APC
Product Details
- Cat. No.
- I-1166
- Clonality
- Monoclonal
- Host
- Rat
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Human
- Clone: MP4-25D2
- Conjugate: Allophycocyanin (APC)
- Isotype: IgG1
- Gene: 3565
Handling
- Quantity: 100 tests
- Storage: This APC conjugate is stable when stored at 2-8°C. Do not freeze.
Applications
- In Situ Hybridization (ISH)