Anti-Human IL-4 - Purified <i>In vivo</i> GOLD™ Functional Grade
Product Details
- Cat. No.
- I-1163- 5 mg
- Clonality
- Monoclonal
- Host
- Rat
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Description
IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Human
- Clone: MP4-25D2
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG1 κ
- Gene: 3565
Handling
- Quantity: 5 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- In Situ Hybridization (ISH)
- Western Blotting (WB)