Anti-Human M-CSF R
Product Details
- Cat. No.
- M1264- 25 µg
- Clonality
- Polyclonal
- Host
- Goat
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Description
Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage.1,2,3 It also triggers growth and development of mononuclear phagocytes and placental trophoblasts.4 M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues5 M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.6
Biological Information
- Clonality: Polyclonal
- Host: Goat
- Reactivity: Human
- Conjugate: Antigen Affinity Purified
- Gene: 1436
Handling
- Quantity: 25 µg
- Storage: The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- In Situ Hybridization (ISH)
- Mass Cytometry (CyTOF)
- Western Blotting (WB)