Product & ReviewsAntibodies

Anti-Human NALP1

Product Details

Cat. No.
N157-0.1 mg
Clonality
Polyclonal
Host
Rabbit
Leinco Technologies

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Description

NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli.1 It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1.2 Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis.3 NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli.4 Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.3

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human
  • Conjugate: Purified No Carrier Protein

Handling

  • Quantity: 0.1 mg
  • Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Applications

  • In Situ Hybridization (ISH)
  • Western Blotting (WB)
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