Anti-Human T Cell Cytokine Receptor (NT) (TCCR)
Product Details
- Cat. No.
- T208-0.1 mg
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-γ and lymphotoxin-β that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned.1,2 It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1.1,2 TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-γ and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph nodes and peripheral blood leukocytes.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Conjugate: Purified No Carrier Protein
Handling
- Quantity: 0.1 mg
- Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.