Product & ReviewsAntibodies
Anti-Human TACE Ectodomain (Clone 111623)
Product Details
- Cat. No.
- T461
- Clonality
- Monoclonal
- Host
- Mouse
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Description
TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.1 TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.2 TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)3 and a principal target for the treatment of TNF-dependent pathologies.4
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: 111623
- Conjugate: Purified No Carrier Protein
- Isotype: IgG1
- Gene: 6868
Handling
- Quantity: 25 µg, 500 µg
- Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Applications
- Western Blotting (WB)