Anti-Human TRAF3
Product Details
- Cat. No.
- T284-0.1 mg
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily.1 TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1.2,3 Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-κB.4 Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-β receptor (LTβR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTβR.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Conjugate: Purified No Carrier Protein
- Gene: 7187
Handling
- Quantity: 0.1 mg
- Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Applications
- Immunohistochemistry (IHC)
- Western Blotting (WB)