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The TWEAK Receptor/FN14, also known as Tumor necrosis factor receptor superfamily member 12A precursor (TNFRSF12A) or fibroblast growth factor-inducable 14, is a secreted type I membrane protein belonging to the distinct superfamily of TNF Receptors. TWEAKR is expressed in many tissues such as the heart, placenta, kidney, pancreas, skeletal muscle and lung. TWEAK R plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis.