Anti-IL2RA monoclonal antibody, clone MEM-181 [Biotin]

Mouse Anti-Human IL2RA monoclonal antibody for FC. Mouse anti Human CD25, clone MEM-181 recognizes the 55kD alpha subunit of the human IL-2 receptor, also known as p55 or TAC antigen, CD25 is a type 1 transmembrane protein with two Sushi domains, also known as short concensus repeats (SCRs) or complement control protein (CCP) modules located within its extracellular domain. The IL-2 receptor exists in three forms. A high affinity form consiting of a non-covalently linked heterodimer composed of the alpha subunit (CD25) and the IL-2 receptor beta subunit also known as CD122 or p75, a medium affinity beta subunit (CD122) monomer or a low affinity alpha (CD25) subunit monomer. CD25 is expressed by activated T lymphocytes and activated B lymphocytes responding to antigen or mitogen stimulation. CD25 is also expressed in some thymocytes and oligodendrocytes. In disease, elevated expression of CD25 in noted in a number of chronic inflammatory conditions, tuberculoid leprosy patients demonstrate markedly elevated levels of circulating CD25high FoxP3+ regulatory T cells (T-regs). Elevated levels of CD25 antigen expression are often seen in cases of non-Hodgkin s lymphoma and diffuse large B cell lymphoma. Flow Cytometry Use 10ul of the suggested working dilution to label 106 cells in 100ul. Applications：FC

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Conjugate: Biotin
• Isotype: IgG1
• Gene: 3559

• Quantity: 100 μg
• Storage: in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

• Flow Cytometry (FC)