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Anti-ITGA6 monoclonal antibody, clone NKI-GoH3 [R-PE]

Product Details

Cat. No.
CABT-46421RH
Type
Primary Antibody
Clonality
Monoclonal
Host
Rat
Creative Diagnostics

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Description

Rat Anti-Human ITGA6 monoclonal antibody for FC. Rat anti Human CD49f antibody, clone NKI-GoH3 recognizes CD49F (VLA-6 alpha chain), a 120kD cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts.VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone NKI-GoH3 specifically blocks the binding of cells to the E8 fragment of laminin. Flow Cytometry Use 10ul of the suggested working dilution to label 106 platelets in 100ul. Applications:FC

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Cynomolgus Monkey, Dog (Canine), Human, Mouse, Pig (Swine), Sheep (Ovine)
  • Conjugate: R-PE
  • Isotype: IgG2a
  • Gene: 3655

Handling

  • Quantity: 100 μg
  • Storage: Prior to reconstitution store at +4°C. Following reconstitution store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Applications

  • Flow Cytometry (FC)
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