Anti-LRP1 monoclonal antibody, clone A2Mr alpha-2 [Biotin]
Product Details
- Cat. No.
- CABT-46866MH
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Mouse Anti-Human LRP1 monoclonal antibody for FC. Mouse anti Human CD91 antibody, clone A2Mr alpha-2 recognizes human CD91, also known as Prolow-density lipoprotein receptor-related protein 1, Alpha-2-macroglobulin receptor or apolipoprotein E receptor. CD91 is a 4525 amino acid protein post translationally cleaved into 3 subunits, a 85kDa type I transmembrane carboxyl chain (LRP85) non-covalently bound to a 515kDa extracellular N-terminal subunit (LRP515)containing multiple EGF-like and LDL-receptor Class A and Class B domains. Additionally, there is an intracellular domain (LRPICD) which can be cleaved from the transmambrane domain by gamma secretase. Clone A2Mr alpha-2 detects an epitope within the LRP515 chain. CD91 is a multifunctional protein involved in processes inluding the phagocytosis and endocytosis of apoptotic cells, clearance of activated serum alpha- 2-macroglobulin, modulation of the inflammatory response and acts as a receptor for Pseudomonas aeruginosa exotoxin A. Mouse anti Human CD91, clone A2Mr alpha-2 has been used extensively for the detection of CD91 by flow cytometry and immunohistochemistry on formalin fixed paraffin embedded tissues. Flow Cytometry Use 10ul of the suggested working dilution to label 106 cells in 100ul. Applications：FC
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Conjugate: Biotin
- Isotype: IgG1
- Gene: 4035
Handling
- Quantity: 100 μg
- Storage: in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- Flow Cytometry (FC)